Gene Expression Signature of Human Polynucleotide Phosphorylase (hPNPaseold-35) in Melanoma

ABSTRACT: Human Polynucleotide Phosphorylase (hPNPaseold-35) is an evolutionarily conserved 3’→5’ exoribonuclease implicated in the regulation of numerous physiological processes like maintenance of mitochondrial homeostasis, mtRNA import and aging-associated inflammation. From an RNase perspective, little is known about the RNA or miRNA species it targets for degradation or whose expression it regulates; except for c-myc and miR-221. To further elucidate the functional implications of hPNPaseold-35 in cellular physiology, we knocked-down and overexpressed hPNPaseold-35 in melanoma cells and performed gene expression analyses to identify differentially expressed transcripts. Biological triplicates were run on microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Dumur Catherine 

PROVIDER: S-ECPF-GEOD-46884 | biostudies-other |

REPOSITORIES: biostudies-other