Co-regulated gene expression by estrogen receptor-? and liver receptor homolog-1 is a feature of the estrogen response in breast cancer cells

ABSTRACT: Estrogen receptor α (ERα) is a nuclear receptor that is the driving transcription factor expressed in the majority of breast cancers. Recent studies have demonstrated that the liver receptor homolog-1 (LRH-1), another nuclear receptor, is ERα-regulated in breast cancer cells. Further, LRH-1 stimulates proliferation and promotes motility and invasion of breast cancer cells. To determine the mechanisms of LRH-1 action in breast cancer cells, we carried out gene expression microarray analysis following siRNA-mediated LRH-1 knockdown. Interestingly, gene ontology (GO) category enrichment analysis of the genes differentially regulated in the presence or absence of LRH-1 identified estrogen responsive genes as the most highly enriched GO categories. To further define LRH-1 target genes, we perfo

ORGANISM(S): Homo sapiens

SUBMITTER: Ali Simak 

PROVIDER: S-ECPF-GEOD-47803 | biostudies-other |

REPOSITORIES: biostudies-other