A nested case-control study to investigate drivers for metastatic disease in breast cancer

ABSTRACT: The purpose of this study was to improve prediction of patients at high-risk for metastatic disease utilizing a nested case-control design that uniquely enables enrichment for relevant phenotypes. We identified all women diagnosed with primary breast cancer from January 1, 1997, to December 31, 2005, in the Stockholm health care region. Patients developing distant metastatic disease (cases) were selected and controls (free from distant disease) were randomly matched by adjuvant therapy, age and calendar period at diagnosis. The nested case-control study included 768 study subjects with clinical information and gene expression arrays (Human Cancer G110). Study subjects were randomly and equally divided into training set (discovery) or testing (validation) set. Metastatic onset prediction wa

ORGANISM(S): Homo sapiens

SUBMITTER: Tobin NP 

PROVIDER: S-ECPF-GEOD-48091 | biostudies-other | 2015 Jan

REPOSITORIES: biostudies-other