Transcription profiling of human breast cancer tumor samples from Uppsala and Singapore cohorts

ABSTRACT: Histological grading of breast cancer defines morphological subtypes informative of metastatic potential, although not without considerable inter-observer disagreement and clinical heterogeneity particularly among the moderately differentiated grade II (G2) tumors. We posited that a gene expression signature capable of discerning tumors of grade I (G1) and grade III (G3) histology might provide a more objective measure of grade with prognostic benefit for patients with moderately differentiated disease. To this end, we studied the expression profiles of 347 primary invasive breast tumors analyzed on Affymetrix microarrays. Using class prediction algorithms, we identified 264 robust grade-associated markers, six of which could accurately classify G1 and G3 tumors, and separate G2 tumors int

ORGANISM(S): Homo sapiens

SUBMITTER: Ivshina AV 

PROVIDER: S-ECPF-GEOD-4922 | biostudies-other | 2006 Nov

REPOSITORIES: biostudies-other