MiRNA expression profiles of peripheral monocytes and glioblastoma-infiltrating macrophages

ABSTRACT: MicroRNAs (miRNAs) are non-coding molecules involved in post-transcriptional gene regulation that have been shown to modulate tumor cell proliferation and apoptosis and to act as oncogenes or tumor-suppressor genes. Although miRNAs have been linked to tumor progression, the connection between tumor-mediated immune modulation and miRNAs has yet to be explored. Specifically, how the miRNA dysregulation affects the monocyte-derived glioblastoma-infiltrating macrophages, the most abundant immune cell population within the glioblastoma microenvironment, and their immune suppressive properties has not been evaluated to date. Here we managed to purify the glioblastoma-infiltrating macrophages from the tumor microenvironment and compared their miRNA expression profile with the matched peripheral m

ORGANISM(S): Homo sapiens

SUBMITTER: Xu S 

PROVIDER: S-ECPF-GEOD-51332 | biostudies-other | 2014 Aug

REPOSITORIES: biostudies-other