HSETD1A cooperates with beta-catenin to regulate Wnt target genes and control colorectal tumor growth

ABSTRACT: Glioblastoma multiforme (GBM) is the most prevalent type of adult brain tumor, and one of the deadliest tumors known to mankind. The genetic understanding of GBM is, however, limited, and the molecular mechanisms which facilitate GBM cell survival and growth within the tumor microenvironment are largely unknown. We applied digital karyotyping and single nucleotide polymorphism (SNP) arrays to screen for copy number changes in GBM samples and found that the most frequently amplified region is at chromosome 7p11.2. The high resolution of digital karyotyping and SNP arrays permits the precise delineation of amplicon boundaries and has enabled identification of the minimal region of amplification at 7p11.2, which contains two genes, EGFR and SEC61γ. SEC61γ encodes a subunit of a heterotrimeric

ORGANISM(S): Homo sapiens

SUBMITTER: Zhou Lei 

PROVIDER: S-ECPF-GEOD-52230 | biostudies-other |

REPOSITORIES: biostudies-other