Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells

ABSTRACT: Cellular plasticity confers cancer cells the ability to adapt to micro-environmental changes, a fundamental requirement for tumour progression and metastasis. The epithelial to mesenchymal transition (EMT) is a transcriptional programme associated with increased cell motility and stemness. Beside EMT, the mesenchymal to amoeboid transition (MAT) has been described during tumour progression but, to date, little is known about its transcriptional control and involvement in stemness. The aim of this study is to investigate (i) the transcriptional profile associated with the MAT programme and (ii) to study whether MAT acquisition in melanoma cancer cells correlate with clonogenic potential to promote tumor growth. Our results demonstrate that MAT programme in melanoma is characterised by incre

ORGANISM(S): Homo sapiens

SUBMITTER: Taddei ML 

PROVIDER: S-ECPF-GEOD-52246 | biostudies-other | 2014

REPOSITORIES: biostudies-other