Expression data from three human cancer cell lines (PC-3, SK-OV-3, WM793B) exposed to experimental cycling and chronic hypoxa in vitro

ABSTRACT: One of the most important features of tumor microenvironment, imposing adverse effect on patient prognosis, is low oxygen tension. There are two types of hypoxia that may occur within tumor mass: chronic and cycling. Preliminary studies point at cycling hypoxia as being more relevant in induction of aggressive phenotype of tumor cells and radioresistance though little is known about the molecular mechanism of this phenomenon. Analysis of gene expression profile of human prostate (PC-3), ovarian (SK-OV-3) and melanoma (WM793B) cancer cells to expermental cycling (interchanging conditions of 1% and 21% oxygen) or chronic (1% oxygen) for 72 hours. Gene expression profiles were analyzed using U133 Plus 2.0 Array (Affymetrix) oligonucleotide microarrays. Data analysis revealed that globally gen

ORGANISM(S): Homo sapiens

SUBMITTER: Olbryt Magdalena 

PROVIDER: S-ECPF-GEOD-53012 | biostudies-other |

REPOSITORIES: biostudies-other