Distinct structural transitions of chromatin topological domains coordinate hormone-induced gene regulation

ABSTRACT: The three-dimensional (3D) organization of the genome within the cell nucleus contributes to cell-specific gene expression in different cell types1. High-throughput 3C–derived methods have revealed that the genome is segmented into contiguous topologically associating domains (TADs), which help to orchestrate gene expression changes during differentiation and development2-5. Using ChIP-Seq, Hi-C and 3D modelling techniques, we reveal that TADs regulate the rapid gene expression changes induced by progestin in T47D breast cancer cells. In response to the hormone, TADs maintain their borders and operate as discrete regulatory units in which the majority of the genes are either transcriptionally activated or repressed. Additionally, the epigenetic signatures of the TADs are coordinately modif

ORGANISM(S): Homo sapiens

SUBMITTER: Le Dily F 

PROVIDER: S-ECPF-GEOD-53463 | biostudies-other | 2014 Oct

REPOSITORIES: biostudies-other