Silica nanoparticles effects on gene expression of A549 cells

ABSTRACT: Expansion of nanotechnology will bring many potential benefits as adversely effects on human health. Protection of the human respiratory system from exposure of volatile nanoparticles has become an emerging health concern. The understanding of the biological processes involved in the development and maintenance of a variety of pathologies is improved by genome-wide approaches. Technical feasibility of this type of experiment has perfected in recent years, but data analysis remains challenging. In this context, gene set analysis has emerged as a fundamental tool for the interpretation of the results. We demonstrate how the use of a combination of gene-by-gene and gene set analyses can enhance the interpretation of results. Gene set analyses are able to distinguish responses due to nanoparti

ORGANISM(S): Homo sapiens

SUBMITTER: Fede C 

PROVIDER: S-ECPF-GEOD-53700 | biostudies-other | 2014 Sep

REPOSITORIES: biostudies-other