RNA sequencing identifies specific PIWI-interacting small non-coding RNA expression patterns in breast cancer

ABSTRACT: PIWI-interacting RNAs (piRNAs) are a novel class of small ncRNAs initially isolated from germ line cells; although recent studies report that they are expressed also in somatic cells. To elucidate the role of piRNAs in somatic cells, in particular from breast cancer, we performed the first extensive next generation sequencing expression analysis of small RNA transcriptomes of hormone responsive breast cancer cell lines in different culture conditions. In addition, to understand the behavior of piRNAs with respect to miRNAs in breast tumor tissues, small RNA sequence data set available in Gene Expression Omnibus (GSE39162) database was used. Results led to the identification of ~100 and ~150 human piRNAs in the breast cancerous cell lines and tumors respectively, several of which different

ORGANISM(S): Homo sapiens

SUBMITTER: Hashim A 

PROVIDER: S-ECPF-GEOD-56134 | biostudies-other | 2014 Oct

REPOSITORIES: biostudies-other