Molecular subtyping of serous ovarian tumors reveals multiple connections to intrinsic breast cancer subtypes

ABSTRACT: Epithelial ovarian cancer is morphologically and clinically heterogeneous. Transcriptional profiling has revealed molecular subtypes (referred to as “C-signatures”) that correlate to biological as well as clinical features. We aimed to determine gene expression differences between malignant, benign and borderline serous ovarian tumors, and to investigate similarities to the intrinsic molecular subtypes of breast cancer. Global gene expression profiling was performed using Illumina's HT12 Bead Arrays and applied to 59 fresh-frozen ovarian tumors. SAM analysis revealed enrichment of cell cycel processes among the malignant tumors, in line with malignant tumors being highly proliferative. The borderline tumors were split between the malignant and benign tumor clusters, indicating that borderl

ORGANISM(S): Homo sapiens

SUBMITTER: Jönsson Jenny-Maria 

PROVIDER: S-ECPF-GEOD-57477 | biostudies-other |

REPOSITORIES: biostudies-other