Expression data from WIF1 induced LN-229 (GBM cell line)

ABSTRACT: Glioblastoma is the most aggressive primary brain tumor in adults and due to the invasive nature it cannot be completely removed. We have recently shown that the WNT inhibitory factor 1 (WIF1), a secreted inhibitor of WNTs, is downregulated in glioblastoma and acts as strong tumor suppressor. In search of a mediator for this function differential gene expression profiles of WIF1-expressing cells were performed. MALAT1, a long non-coding RNA and key positive regulator of invasion, emerged as the top downregulated gene. Indeed, knock-down of MALAT1 reduced migration in glioblastoma cells, without effect on proliferation. LN-229 cells induced with Doxocyclin to express WIF1 were compared to the non-induced control (two biological replicates each)

ORGANISM(S): Homo sapiens

SUBMITTER: Vassallo Irene 

PROVIDER: S-ECPF-GEOD-58525 | biostudies-other |

REPOSITORIES: biostudies-other