Stromal and epithelial changes in breast cancer following endocrine treatment

ABSTRACT: Patients diagnosed with breast cancer were recruited to an important trial, the Tamoxifen Window Trial, in two series, series A during 1988-1989 and series B during 1989-1990. Some patients received tamoxifen for short windows. Clinical samples (biopsies) for this trial were collected before and after treatment. These biopsies were available as formalin-fixed paraffin-embedded (FFPE) tissue blocks. Responding patients and non-responding patients were determined by the change in the Ki67 scores. Responding patients were identified as those that had demonstrated a reduction in their Ki67 scores, and non-responding patients were identified as those in which Ki67 had not changed or had increased. The change in the percentage of Ki67 positive tumour cells was obtained by comparing the pre-treat

ORGANISM(S): Homo sapiens

SUBMITTER: Azadbakht Narges 

PROVIDER: S-ECPF-GEOD-58598 | biostudies-other |

REPOSITORIES: biostudies-other