Transcription profiling of human lung cancers for molecular discrimination and characterization

ABSTRACT: Lung cancers are a heterogeneous group of diseases with respect to biology and clinical behavior. So far, diagnosis and classification are based on histological morphology and immunohistological methods for discrimination between two main histologic groups: small cell lung cancer (SCLC) and non-small cell lung cancer which account for 20% and 80% of lung carcinomas, respectively. While SCLCs express properties of neuroendocrine cells, NSCLCs, which are divided into the three major subtypes adenocarcinoma, squamous cell carcinoma and dedifferentiated large cell carcinoma, show different characteristics such as the expression of certain keratins or production of mucin and lack neuroedocrine differentiation. The molecular pathogenesis of lung cancer involves the accumulation of genetic und ep

ORGANISM(S): Homo sapiens

SUBMITTER: Rosskopf Michael 

PROVIDER: S-ECPF-GEOD-6044 | biostudies-other |

REPOSITORIES: biostudies-other