Expression data from transformed WT and HGPS cell lines, including HGPS cells after knock-down of BRD4

ABSTRACT: Primary skin fibroblasts from a HGPS patient and an age-matched control wild-type individual were challenged in a standard transformation assay by retroviral introduction of TERT (T), V12-HRAS (R) and SV40 large and small T antigens (S). Knock-down of BRD4 in this TRS-HGPS cell line (TRS-HGPS-shBRD4) was achieved by retroviral introduction of independent shRNAs (shBRD4-1 to -3) Abstract: Advanced age and DNA damage accumulation are strong risk factors for cancer. The premature-aging disorder Hutchinson Gilford Progeria Syndrome (HGPS) provides a unique opportunity to study the interplay between DNA damage and aging-associated tumor mechanisms, since HGPS patients do not develop tumors despite elevated levels of DNA damage. Here, we have used HGPS patient cells to identify a protective mec

ORGANISM(S): Homo sapiens

SUBMITTER: Fernandez Ferri Patricia 

PROVIDER: S-ECPF-GEOD-60519 | biostudies-other |

REPOSITORIES: biostudies-other