Effect of cajanin stilbene acid and its synthetic derivatives on MCF-7 breast cancer cells

ABSTRACT: Cajanin stilbene acid (CSA) was previously shown to induce cytotoxicity against cancer cells. We have employed microarray gene expression profiling to identify deregulated genes in MCF-7 breast cancer cells upon treatment with CSA and its synthetic derivatives (CSA6, CSA9, CSA19). TGM2 gene encoding transglutaminase 2 was commonly deregulated after treatment with all four CSA compounds. All compounds revealed strong effects on cell cycle progression and DNA damage response. Promoter motif analysis of the deregulated genes further supported the microarray results emphasizing the relevance of transcription factors regulating cell cycle and proliferation, MYC being among the most pronounced ones. Interestingly, cellular movement was among the top five affected cellular functions after treatme

ORGANISM(S): Homo sapiens

SUBMITTER: Kadioglu O 

PROVIDER: S-ECPF-GEOD-64430 | biostudies-other | 2015 Feb

REPOSITORIES: biostudies-other