EMT Alters Interstitial Fluid Flow-induced Signaling in ERBB2-positive Breast Cancer

ABSTRACT: A variety of mechanotransduction forces are altered in the tumor microenvironment (TME) and these biophysical forces can influence cancer progression. One such force is interstitial fluid flow (IFF) - the movement of fluid through the tissue matrix. IFF was previously shown to induce invasion of cancer cells, but the activated signaling cascades remain poorly understood. Here, it is demonstrated that IFF induces invasion of ERBB2/HER2 expressing breast cancer cells via activation of phosphoinositide-3-kinase (PI3K). In constitutively activate ERBB2 expressing cells that have undergone epithelial-to-mesenchymal transition (EMT), IFF-mediated invasion requires the chemokine receptor CXCR4, a gradient of its ligand CXCL12, and activity of the PI3K catalytic subunits p110a and β. In wild-type

ORGANISM(S): Homo sapiens

SUBMITTER: Tchafa Alimatou 

PROVIDER: S-ECPF-GEOD-64670 | biostudies-other |

REPOSITORIES: biostudies-other