Integrated genomic and transcriptional profiling yields putative marker genes for cervical cancer

ABSTRACT: A better understanding of the consequences of recurrent (epi)genetic alterations that occur during cervical carcinogenesis is essential in the search for novel biomarkers. In this study we determined genome-wide expression profiles of 10 squamous cell carcinomas (SCCs), 5 adenocarcinomas (AdCAs) and 6 normal epithelial samples. Expression patterns were subsequently combined with previously determined chromosomal profiles in the same carcinomas. Differential gene expression analysis identified 76 genes with altered expression in carcinomas compared to normal epithelium. Microarray results for a subset of these genes were validated by real-time RT-PCR. Among the differentially expressed genes a relative overrepresentation of genes located at chromosome 3q, one of the most frequently gained

ORGANISM(S): Homo sapiens

SUBMITTER: Wilting SM 

PROVIDER: S-ECPF-GEOD-6473 | biostudies-other | 2008 Oct

REPOSITORIES: biostudies-other