Comparative analysis of monocytes from healthy donors, patients with metastatic breast cancer, sepsis or tuberculosis

ABSTRACT: Myeloid-derived suppressor cells (MDSCs) are highly immunosuppressive myeloid cells, which increase in cancer patients. The molecular mechanism behind their generation and function is unclear. Whereas granulocytic-MDSCs correlate with poor overall survival in breast cancer, the presence and relevance of monocytic-MDSCs (Mo-MDSCs) is unknown. Here we report for the first time an enrichment of functional blood Mo-MDSCs in breast cancer patients before they acquire a typical Mo-MDSC surface phenotype. A clear population of Mo-MDSCs with the typical cell surface phenotype (CD14+HLA-DRlow/-Co-receptorlow/-) increased significantly first during disease progression and correlated to metastasis to lymph nodes and visceral organs. Furthermore, monocytes, comprising the Mo-MDSC population, from pati

ORGANISM(S): Homo sapiens

SUBMITTER: von Stedingk Kristoffer 

PROVIDER: S-ECPF-GEOD-65517 | biostudies-other |

REPOSITORIES: biostudies-other