Human melanoma transcriptom is modulated by cold plasma treatment

ABSTRACT: Treatment of tumor progression and metastasis continues to be of major importance in the field of cancer. It is reported that cancer cells often show a pronounced sensitivity towards oxidative stress. Cold plasma offers the ability to deliver a delicate mix of reactive oxygen and nitrogen species directly into cells or tissues. Using a well-described argon plasma jet, we investigated the biological responses of plasma on tumor cell death, cell migration, and expression of adhesion-associated genes as well as cytoskeletal modifications. Using the human melanoma cancer cell line SK-Mel-147 we were able to show that plasma induced only little apoptosis but had profound effects on tumor cell motility. Plasma treatment of cells was associated with an inhibition of migration and disorganization

ORGANISM(S): Homo sapiens

SUBMITTER: Schmidt Anke 

PROVIDER: S-ECPF-GEOD-65972 | biostudies-other |

REPOSITORIES: biostudies-other