Expression data of human neuroblastoma IMR32 cells treated with the DHODH inhibitor Teriflunomide [118 µM]

ABSTRACT: Neuroblastoma is an embryonal tumor which originates from neural crest progenitor cells that fail to differentiate along their predefined route to sympathetic neurons or sympatho-adrenergic adrenal cells. It is the most common extracranial tumor of childhood and accounts for 15% of all childhood cancer deaths. Especially patients suffering from high grade or relapsed neuroblastoma have poor outcome in spite of aggressive treatment regimens including autologous stem cell transplantation. Those patients are in urgent need of additional effective therapies which demands the development of targeted approaches. Dihydroorotatedehydrogenase (DHODH) is the fourth enzyme of the pyrimidine synthesis pathway which oxidizes dihydroorotate to orotate. In recent past it became a potential drug target fo

ORGANISM(S): Homo sapiens

SUBMITTER: Lindner Sven 

PROVIDER: S-ECPF-GEOD-67338 | biostudies-other |

REPOSITORIES: biostudies-other