Transcription profiling of human MCF7 cell response toCimicfuga racemosa (black cohosh)

ABSTRACT: Extracts from the rhizome of Cimicifuga racemosa (black cohosh) are increasingly popular as herbal alternative to hormone replacement therapy (HRT) for the alleviation of postmenopausal disorders. However, the molecular mode of action and the active principles are presently not clear. Previously published data have been largely contradictory. We, therefore, investigated the effects of a lipophilic Cimicifuga rhizome extract on the ER+ breast cancer MCF-7 cells at transcriptional level in comparision to 17beta-estradiol and the ER antagonist tamoxifen. With the extract 431 genes were regulated more than 1.5 fold. The overall expression pattern differed from those of 17β-estradiol or the estrogen receptor antagonist tamoxifen. We observed an enrichment of genes in an anti-proliferative and a

ORGANISM(S): Homo sapiens

SUBMITTER: Gaube F 

PROVIDER: S-ECPF-GEOD-6800 | biostudies-other | 2007

REPOSITORIES: biostudies-other