Transcription profiling of human SK-Mel-28 Cell Line

ABSTRACT: Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin. MTf is expressed at very low levels in normal tissues and in high amounts in melanoma cells. The over-expression of MTf in tumor cells was hypothesized to assist rapidly proliferating neoplastic cells with their increased Fe requirements. However, our recent characterization of the MTf knockout (MTf -/-) mouse demonstrated that MTf did not have an essential role in Fe metabolism. To understand the function of MTf, we utilized whole-genome microarray analysis to examine the gene expression profile of five models after modulating MTf expression. These models included two new stably transfected MTf hyper-expression models (SK-N-MC neuroepithelioma and LMTK- fibroblast

ORGANISM(S): Homo sapiens

SUBMITTER: Rahmanto Yohan Suryo 

PROVIDER: S-ECPF-GEOD-6817 | biostudies-other |

REPOSITORIES: biostudies-other