Transcription profiling of human A549 induced tumours in mice treated with PCI-5002, PCI-5003, or control vehicle

ABSTRACT: We have demonstrated that water-soluble zinc ionophores can be administered to mice at relatively high doses and inhibit the growth of A549 lung cancer cells grown in xenograft models. Gene expression profiles of tumor specimens harvested from mice four hours after treatment confirmed that the activation of stress responsive genes occurs in vivo. These findings lead us to propose that the pharmacologic delivery of zinc to tumors using water solubilized ionophores is a potential approach to cancer therapy. Experiment Overall Design: 1.25 million A549 cells were injected subcutaneously/intramuscularly into the right hind flank of 6 week old CD-1 nude mice that had been irradiated with 4 Gy of total body irradiation from a 137Cs radiation source one day prior to tumor implantation. When t

ORGANISM(S): Homo sapiens

SUBMITTER: Hacia Joseph Gerard 

PROVIDER: S-ECPF-GEOD-6962 | biostudies-other |

REPOSITORIES: biostudies-other