Identification of differentially regulated splice variants and novel exons in glial brain tumors using exon arrays

ABSTRACT: Aberrant splice variants are involved in the initiation and/or progression of glial brain tumors. We therefore set out to identify splice variants that are differentially expressed between histological subgroups of gliomas. Splice variants were identified using a novel platform that profiles the expression of virtually all known and predicted exons present in the human genome. Exon-level expression profiling was performed on 26 glioblastomas, 22 oligodendrogliomas and 6 control brain samples. Our results demonstrate that Human Exon arrays can identify subgroups of gliomas based on their histological appearance and genetic aberrations. We next used our expression data to identify differentially expressed splice variants. In two independent approaches, we identified 49 and up to 459 exons th

ORGANISM(S): Homo sapiens

SUBMITTER: French PJ 

PROVIDER: S-ECPF-GEOD-9385 | biostudies-other | 2007 Jun

REPOSITORIES: biostudies-other