Gene expression analysis of pre-defined sets of neoplastic tissues

ABSTRACT: To identify a group of genes, characteristic of a single neoplasia and determinant for the risk to relapse, we have performed gene expression analysis of ductal breast carcinoma samples using Affymetrix oligonucletide microarray (HU133A). Biopses from 60 patients, 30 good prognosis (desease free from six to ten years after surgical treatment) and 30 poor prognosis, have been analyzed. From each group we have created six homogeneous pools to show, during the analysis, only genes expressed in a greatly different way. A reduced number of cases has been used to avoid dilution of genes expressed only in few samples. Analysis have identified 77 candidate genes with a specific ontological distribution that contained some genes that were linked to breast cancer by previous studies. Microarray resu

ORGANISM(S): Homo sapiens

SUBMITTER: Cimino Daniela 

PROVIDER: S-ECPF-GEOD-9662 | biostudies-other |

REPOSITORIES: biostudies-other