Transcription profiling on non-small cell lung cancer samples reveals CYP3A5 gene expression is associated with early recurrence

ABSTRACT: Study to identify genes associated with NSCLC recurrence in patients not receiving adjuvant chemotherapy. Purpose: Recent clinical trials suggest improvement in survival with adjuvant chemotherapy in non-small cell lung cancer (NSCLC). This study's aim is to identify genes associated with NSCLC recurrence in patients not receiving adjuvant chemotherapy. Experimental design: Banked NSCLC tumors of patients who underwent resection of stage Ia-IIIb disease were identified. Patients were stratified into two groups: recurrent (R, n=11) or non-recurrent (NR, n=16) 2 years after surgery. Microarray profiling and Cox multivariate analysis were performed. Conclusion: Increased CYP3A5 gene expression correlates with NSCLC recurrence and promotes proliferation through mechanisms that may involve

ORGANISM(S): Homo sapiens

SUBMITTER: Potter David 

PROVIDER: S-ECPF-GEOD-9971 | biostudies-other |

REPOSITORIES: biostudies-other