Transcription profiling by array of human malignant melanoma cell line, A375, following interferon-gamma-induced gene transcription

ABSTRACT: MicroRNAs are major regulators of post-transcriptional gene regulation. Even small changes in miRNA levels may have profound consequences for the expression levels of target genes. Hence, miRNAs themselves need to be tightly, albeit dynamically, regulated. Here, we investigated the dynamic behaviour of miRNAs over a wide time range following transcriptional activation of melanoma cells by interferon-? (IFN-?), which activates the transcription factor STAT1. By applying several software packages for analyses, visualisation and identification of differentially expressed miRNAs derived from time-series microarray experiments, 8.9% (98) of 1102 miRNAs appeared to be directly or indirectly regulated by STAT1. Focussing on distinct dynamic expression patterns, we found that the majority of diffe

ORGANISM(S): Homo sapiens

SUBMITTER: Reinsbach S 

PROVIDER: S-ECPF-MEXP-3544 | biostudies-other | 2012 Jul

REPOSITORIES: biostudies-other