MicroRNA expression as risk biomarkers of breast cancer metastasis in a retrospective case cohort study

ABSTRACT: Introduction: MicroRNAs (miRNAs) are small, non-coding RNA molecules involved in post-transcriptional gene regulation and have recently been shown to play a role in cancer metastasis. In solid tumors, especially breast cancer, alterations in miRNA expression contribute to cancer pathogenesis, including metastasis. Considering the emerging role of miRNAs in metastasis, the identification of predictive markers is necessary to further understanding of stage-specific breast cancer development. This is a retrospective analysis that aimed to identify molecular biomarkers related to distant breast cancer metastasis development.

Methods: A retrospective case cohort study was performed in 64 breast cancer patients treated during the period from 1998-2001. The case group (n=29) consisted of p

ORGANISM(S): Homo sapiens

SUBMITTER: Marques Marcia 

PROVIDER: S-ECPF-MEXP-3947 | biostudies-other |

REPOSITORIES: biostudies-other