Transcription profiling by array of 17 human breast cancer samples

ABSTRACT: Cancer evolves dynamically, as clonal expansions supersede or overlap one another, driven by shifting selective pressures, mutational processes and disrupted cancer genes. These processes mark the genome, such that a cancer's life history is encrypted in the timing, ploidy, clonality and patterns of somatic mutation. We developed bioinformatic algorithms to decipher this narrative, and applied them to 21 breast cancer genomes. We find that mutational processes evolve across the lifespan of a breast tumor, with cancer-specific signatures of point mutations and chromosomal instability often emerging late but contributing extensive genetic variation. Subclonal diversification is prominent, providing insight into the dynamics of clonal expansion in breast cancer. Most point mutations are found

ORGANISM(S): Homo sapiens

SUBMITTER: McLaren Stuart 

PROVIDER: S-ECPF-MTAB-1088 | biostudies-other |

REPOSITORIES: biostudies-other