Transcription profling by array of respiratory tract samples from smokers and non-smokers with/without cancers (of lung or Head and Neck) and with/without chronic obstructive pulmonary disease (COPD)

ABSTRACT: Cigarette smoking is the major cause of cancers of the respiratory tract, including non-small cell lung cancer (NSCLC) and head and neck cancer (HNC). In order to better understand carcinogenesis of the lung and upper airways, we have compared the gene expression profiles of tumour-distant, histologically normal bronchial biopsy specimens obtained from current smokers with NSCLC or HNC (SC, considered as a single group), as well as non-smokers (NS) and smokers without cancer (SNC). RNA from a total of 97 biopsies was used for gene expression profiling (Affymetrix HG-U133 Plus 2.0 array). Differentially expressed genes were used to compare NS, SNC, and SC, and functional analysis was carried out using Ingenuity Pathway Analysis (IPA). Smoking-related cancer of the respiratory tract was foun

ORGANISM(S): Homo sapiens

SUBMITTER: Van Dyck E 

PROVIDER: S-ECPF-MTAB-1690 | biostudies-other | 2014 Apr

REPOSITORIES: biostudies-other