Transcription profiling by array of human HeLa cells with M1775R and A1789T BRCA1 missense mutations

ABSTRACT: BRCA1 (breast cancer 1, early onset) mutations confer a high breast and ovarian cancer risk. Most of BRCA1 cancer-predisposing mutations originate truncated proteins, but missense mutations have also been detected in familial breast and ovarian cancer patients. These variants are rare and their role in cancer predisposition is often difficult to ascertain. Our purpose in the present work was to study the molecular mechanisms affected in human cells by two BRCA1 missense variants both located in the second BRCA1 BRCT domain, M1775R and A1789T. These variants were isolated from familial breast cancer patients and their role in the pathogenesis of breast cancer was also investigated by a study previously performed by our group in yeast cells. Here we present a microarray study to compare the

ORGANISM(S): Homo sapiens

SUBMITTER: Iofrida C 

PROVIDER: S-ECPF-MTAB-761 | biostudies-other | 2012

REPOSITORIES: biostudies-other