Project description:While transcriptional regulation of stem cell self-renewal and differentiation has been extensively studied, only a small number of studies have addressed the roles for post-translational modifications in these processes. A key mechanism of post-translational modification is ubiquitination by the ubiquitin-proteasome system (UPS). Using UPS-targeted RNAi screens, we identify novel regulators of pluripotency and differentiation. We focus on two of these proteins, the deubiquitinating enzyme, Psmd14, and the E3 ligase, Fbxw7, and characterize their importance in ES cell pluripotency and cellular reprogramming.

2012-08-01 | GSE39771 | GEO

Expression data from embryonic stem cells following siRNA transfection of UPS members [Differentiation_ES]

2012-08-01 | GSE39770 | GEO

Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy.

Project description: Not available

| S-EPMC7041410 | biostudies-literature

Enhanced Bone Marrow Homing of Natural Killer Cells Following mRNA Transfection With Gain-of-Function Variant CXCR4<sup>R334X</sup>.

Project description: Not available

| S-EPMC6560173 | biostudies-literature

PCR Array Profiling of miRNA Expression Involved in the Differentiation of Amniotic Fluid Stem Cells toward Endothelial and Smooth Muscle Progenitor Cells.

Project description: Not available

| S-EPMC10779355 | biostudies-literature