Degradation of purines: only ureidoglycollate lyase out of four allantoin-degrading enzymes is present in mammals.

ABSTRACT: It is generally accepted that all of the allantoin-degrading enzymes (allantoinase, allantoicase, ureidoglycollate lyase and urease), used in purine degradation, were lost during mammalian evolution. However, surprisingly, ureidoglycollate lyase has been found in a mammalian tissue. Ureidoglycollate lyase was purified to homogeneity and characterized from rat-liver mitochondria. The apparent Km (17 mM) of the rat enzyme for ureidoglycollate was much higher than that (0.33 mM) of fish-liver ureidoglycollate lyase. The rat-liver enzyme differed from the fish-liver enzyme in enzymic, physical and immunological properties.

SUBMITTER: Fujiwara S 

PROVIDER: S-EPMC1136261 | biostudies-other | 1995 Nov

REPOSITORIES: biostudies-other