Cloning and expression of protein tyrosine phosphatase-like protein derived from a rat pheochromocytoma cell line.

ABSTRACT: A novel protein [designated protein tyrosine phosphatase-like protein (PTPLP)] which is distantly related to receptor-type protein tyrosine phosphatases (PTPases) was cloned from a rat pheochromocytoma cell line. The PTPLP was detected exclusively in the brain. Overexpression of the PTPLP decreased the basal PTPase activity of COS-7 cells for Raytide. These results suggest that PTPLP may function as a negative regulator of PTPases in neuronal tissues.

SUBMITTER: Kambayashi Y 

PROVIDER: S-EPMC1136525 | biostudies-other | 1995 Mar

REPOSITORIES: biostudies-other