The human phenolsulphotransferase polymorphism is determined by the level of expression of the enzyme protein.

ABSTRACT: We have examined the expression of platelet phenolsulphotransferase (PST) in 60 individuals. Using an antibody which recognizes both forms of PST present in man (P-PST and M-PST), we determined that the polymorphism of platelet P-PST activity is determined by the level of expression of the enzyme protein. The implications for susceptibility to adverse drug reactions and chemical carcinogenesis are discussed.

SUBMITTER: Jones AL 

PROVIDER: S-EPMC1137690 | biostudies-other | 1993 Dec

REPOSITORIES: biostudies-other