Involvement of calcium ions in the activation of ornithine decarboxylase by isoprenaline evaluated 'in situ' in the perfused rat heart.

ABSTRACT: Ornithine decarboxylase activity evaluated during the perfusion of isolated rat hearts by a method 'in situ' was rapidly increased when the hearts were infused with isoprenaline (isoproterenol). Omission of Ca2+ from the perfusion medium or the administration of verapamil to the perfused hearts decreased the isoprenaline-stimulated ornithine decarboxylase activity, whereas a marked stimulatory effect was registered when the hearts were perfused with the Ca2+ ionophore A23187.

SUBMITTER: Guarnieri C 

PROVIDER: S-EPMC1152035 | biostudies-other | 1983 Apr

REPOSITORIES: biostudies-other