Mechanism of enhanced RNA synthesis in acute-phase rat liver and its relationship to chromatin structure.

ABSTRACT: Nuclei isolated from the liver of rats undergoing an acute inflammatory reaction induced by turpentine treatment show increased RNA synthesis. This increase is essentially determined by a faster polyribonucleotide-elongation rate while the number of transcribing polymerase molecules is unchanged. The sensitivity of chromatin to micrococcal-nuclease digestion and the composition of chromosomal proteins are not affected by the acute-phase process. Therefore the increased RNA synthesis by liver nuclei from acutely inflamed rats does not seem to correlate with major changes in chromatin structure.

SUBMITTER: Schiaffonati L 

PROVIDER: S-EPMC1153461 | biostudies-other | 1984 Apr

REPOSITORIES: biostudies-other