Proteolytic activation can produce a phosphatidylinositol phosphodiesterase highly sensitive to Ca2+.

ABSTRACT: The phosphatidylinositol phosphodiesterase of rat brain shows little activity under conditions likely to pertain in vivo (neutral pH and micromolar Ca(2+) concentrations). A short incubation of a brain supernatant with trypsin, or a longer pre-incubation of the supernatant alone, produce new forms of the enzyme, which are active under such conditions. A possible role of receptor-linked proteinases in initiating phosphatidylinositol catabolism is discussed.

SUBMITTER: Hirasawa K 

PROVIDER: S-EPMC1158640 | biostudies-other | 1982 Sep

REPOSITORIES: biostudies-other