Molecular conformation of sodium heparan sulphate in the condensed phase.

ABSTRACT: By using the X-ray-diffraction results reported previously for sodium heparan sulphate, a twofold helical conformation with an axially projected disaccharide repeat (h) equal to 0.93 nm has been examined in detail. On the basis of a repeating sequence of 1,4-alpha-D-glucosamine and 1,4-beta-D-glucuronic acid, trial and stereochemically feasible molecular models were computer-generated. An optimum twofold helical conformation is proposed, incorporating stabilizing intra-chain hydrogen bonds across both glycosidic linkages.

SUBMITTER: Elloway HF 

PROVIDER: S-EPMC1164533 | biostudies-other | 1977 Mar

REPOSITORIES: biostudies-other