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Stereochemical considerations for constructing alpha-helical protein bundles with particular application to membrane proteins.


ABSTRACT: The stereochemical constraints originally used to construct two- and three-stranded alpha-helical coiled-coils were generalized for aggregates of alpha-helices containing from 4 to 14 alpha-helices in tubular bundles. Certain features of bacteriorhodopsin show excellent correlations with these stereochemical constraints.

SUBMITTER: Dunker AK 

PROVIDER: S-EPMC1164662 | biostudies-other | 1977 Apr

REPOSITORIES: biostudies-other

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