Ontology highlight
ABSTRACT:
SUBMITTER: Lang J
PROVIDER: S-EPMC1170414 | biostudies-other | 1998 Feb
REPOSITORIES: biostudies-other
The EMBO journal 19980201 3
alpha-Latrotoxin (alpha-LTX) induces exocytosis of small synaptic vesicles (SSVs) in neuronal cells both by a calcium-independent mechanism and by opening cation-permeable pores. Since the basic molecular events regulating exocytosis in neurons and endocrine cells may be similar, we have used the exocytosis of insulin-containing large dense core vesicles (LDCVs) as a model system. In primary pancreatic beta-cells and in the derived cell lines INS-1 and MIN6, alpha-LTX increased insulin release i ...[more]