Acute effects of carbon monoxide on the metabolism of perfused rat liver.

ABSTRACT: 1. Perfusion of livers with whole blood containing carboxyhaemoglobin decreased hepatic O(2) consumption and triglyceride secretion and raised free fatty acid oxidation. 2. Perfusion with [(14)C]carboxyhaemoglobin indicated that there was negligible hepatic uptake of (14)CO. 3. The observations appear to be due to a decrease in O(2) consumption rather than to specific effects of carboxyhaemoglobin.

SUBMITTER: Topping DL 

PROVIDER: S-EPMC1172488 | biostudies-other | 1975 Nov

REPOSITORIES: biostudies-other