Studies on human N-acetyl-Beta-d-hexosaminidase C separated from neonatal brain.

ABSTRACT: Human brain hexosaminidase C was separated from isoenzymes A and B by Sephadex G-200 gel filtration. Properties of the enzyme were studied, particularly its isoelectric-focusing profile, pI4.80. These findings indicate that hexosaminidase C is identical with the major residual component of Sandhoff fibroblasts with respect to substrate specificity, pI and activity pH optimum.

SUBMITTER: Besley GT 

PROVIDER: S-EPMC1172820 | biostudies-other | 1976 Apr

REPOSITORIES: biostudies-other