Inhibition of pig kidney diamine oxidase by substrate analogues.

ABSTRACT: 1. The oxidation of p-dimethylaminomethylbenzylamine was followed spectrophotometrically by measuring the change in E(250) caused by the p-dimethylaminomethylbenzaldehyde produced. 2. This reaction was inhibited by substrate analogues such as isothiouronium, guanidino, dimethylsulphonium and trimethylammonium compounds. 3. The inhibition by both mono- and bis-onium compounds has been studied and a comprehensive theory is developed to explain both the type and degree of inhibition produced.

SUBMITTER: Bardsley WG 

PROVIDER: S-EPMC1173761 | biostudies-other | 1972 Jun

REPOSITORIES: biostudies-other