Aberration of porphyrin metabolism in iron-deficient anaemic rats.

ABSTRACT: Iron-deficient rats excreted greater amounts of 5-aminolaevulinate in urine but the output of porphobilinogen was decreased considerably. In addition, activity of the enzyme 5-aminolaevulinate dehydratase was diminished in bone marrow and liver. The results suggest that in iron deficiency a defect occurs in porphyrin synthesis at the level of porphobilinogen formation.

SUBMITTER: Sharma DC 

PROVIDER: S-EPMC1177881 | biostudies-other | 1973 Jul

REPOSITORIES: biostudies-other