The metabolism of acetamidothiazoles in the rat. 2-acetamido-4-chloromethylthiazole.

ABSTRACT: 2-Acetamido-4-chloromethylthiazole is metabolized in the rat to (2-acetamido-4-thiazolylmethyl)mercapturic acid and 2-acetamidothiazole-4-carboxylic acid. 2-Acetamido-4-methylthiomethylthiazole and the corresponding sulphoxide and sulphone are also produced as minor metabolites. The identification of the metabolites is described and their formation investigated. Quantitative results on the excretion of the metabolites labelled with (14)C are reported.

SUBMITTER: Chatfield DH 

PROVIDER: S-EPMC1177895 | biostudies-other | 1973 Aug

REPOSITORIES: biostudies-other