Thyroid-hormone modulation of the number of beta-adrenergic receptors in rat fat-cell membranes.

ABSTRACT: Adipocytes from thyroidectomized rats contain 3 times less [3H]dihydroalprenolol-binding sites (beta-adrenergic receptors) than adipocytes from euthyroid animals. This alteration is not solely due to cell-size differences, but also to a thyroidectomy-induced defect in beta-adrenergic receptor density per adipocyte surface area, a defect that is furthermore corrected by tri-iodothyronine treatment.

SUBMITTER: Giudicelli Y 

PROVIDER: S-EPMC1186327 | biostudies-other | 1978 Dec

REPOSITORIES: biostudies-other