Involvement of cytoskeletal structures in nerve-growth-factor-mediated induction of ornithine decarboxylase.

ABSTRACT: Induction of ornithine decarboxylase elicited in response to nerve-growth factor in target organs is greatly decreased by preincubation of these tissues with cytoskeletal poisons such as vinblastine, diamide, cytochalasin B and colchicine. These results are interpreted as evidence for the involvement of receptor-associated cytoskeletal structures in mediating the nerve-growth-factor-specific induction of ornithine decarboxylase.

SUBMITTER: Lakshmanan J 

PROVIDER: S-EPMC1186504 | biostudies-other | 1979 Jan

REPOSITORIES: biostudies-other